ACIDUM NIFLUMICUM

ACIDUM NIFLUMICUM - Names and Identifiers

Name	Niflumic acid
Synonyms	Niflumic acid ACIDUM NIFLUMICUM Niflumic acid solution,100ppm ACIDUMNIFLUMICUM(NIFLUMICACID) Nicotinic acid Solution, 100ppm 2-[3-(Trifluoromethyl)anilino]nicotinic acid 2-(α,α,α-trifluoro-m-toluidino)nicotinic acid 2-{[3-(trifluoromethyl)phenyl]amino}nicotinic acid 2-[3-(Trifluoromethyl)-phenyl]aminonicotinic acid 2-(alpha,alpha,alpha-trifluoro-m-toluidino)nicotinic acid 2-{[3-(trifluoromethyl)phenyl]amino}pyridine-3-carboxylate 2-[(3-Trifluoromethylphenyl)amino]nicotinic AcidNiflumic Acid 2-[3-(Trifluoromethyl)anilino]nicotinic acid, 2-(α,α,α-Trifluoro-m-toluidino)nicotinic acid
CAS	4394-00-7
EINECS	224-516-2
InChI	InChI=1/C13H9F3N2O2/c14-13(15,16)8-3-1-4-9(7-8)18-11-10(12(19)20)5-2-6-17-11/h1-7H,(H,17,18)(H,19,20)/p-1
InChIKey	JZFPYUNJRRFVQU-UHFFFAOYSA-N

ACIDUM NIFLUMICUM - Physico-chemical Properties

Molecular Formula	C13H9F3N2O2
Molar Mass	282.22
Density	1.3935 (estimate)
Melting Point	203-204 °C
Boling Point	378.0±42.0 °C(Predicted)
Flash Point	182.4°C
Water Solubility	19mg/L(room temperature)
Solubility	Soluble in ethanol (~50 mg/ml), acetone (50 mg/ml, Clear to Slightly Hazy, Yellow), methanol (~50 mg/ml), DMSO (56 mg/ml at 25°C), and acetonitrile (~50 mg/ml).
Vapor Presure	2.18E-06mmHg at 25°C
Appearance	Bright yellow crystal
Color	Light orange to Yellow to Green
Merck	14,6531
pKa	pKa 2.26 ± 0.08;4.44± 0.03(H2O,t =25±0.1,I=0.01(NaCl))(Approximate)
Storage Condition	2-8°C
Stability	Stable, but may discolour in light. Incompatible with strong oxidizing agents. Hygroscopic.
Sensitive	Light Sensitive
MDL	MFCD00010569
Use	Used as a pharmaceutical Intermediate
In vitro study	Niflumic acid inhibits Calcium-activated chloride channels with an inhibition constant of 17 mM. Niflumic acid can also inhibit ICl (CA) caused by calcium ions. Calcium ions enter oocytes through ionophore A23187, indicating that the inhibition of ICl (CA) is due to the direct combination with chloride ion channels, rather than by interference through voltage-dependent calcium channels. In the basolateral membrane of rat pancreatic exocrine cells, Niflumic acid inhibits calcium ion activation with an IC 50 of 50 μm. Niflumic acid dose-dependently and reversibly activates Calcium-activated kryptine (KCa) channels. Niflumic acid produces the amplitude of an inward current (STIC, Calcium-activated chloride current) of spontaneous transient concentration-dependent inhibition. Niflumic acid inhibited IO(Ca) evoked by noradrenaline and caffeine with an IC50 of 6.6 μm, which was weaker than the current evoked by spontaneous currents. Niflumic acid voltage-dependent suppression of spontaneous transient current (STIC) amplitude, with IC50 of 2.3 μm and 1.1 μm at -50 mV and 50 mV, respectively. Niflumic acid not only inhibits IL-13-induced goblet cell hyperplasia, but also inhibits airway hyperresponsiveness and eosinophil invasion. After IL-13 instillation, Niflumic acid inhibited chemokine levels in bronchoalveolar lavage fluid and overexpression of the MUC5AC gene, MUC5A a marker of goblet cell hyperplasia. Niflumic acid inhibits JAK2 activation, STAT6 activation, and chemokine expression in epithelial cells.

ACIDUM NIFLUMICUM - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
UN IDs	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	QT2999100
HS Code	29333999
Hazard Class	6.1
Packing Group	Ⅲ
Toxicity	LD50 in rats (mg/kg): 370 orally; 155 i.p. (Sorenson)

ACIDUM NIFLUMICUM - Reference Information

NIST chemical information	Information provided by: webbook.nist.gov (external link)
EPA chemical information	Information provided by: ofmpub.epa.gov (external link)
pharmacological effects	niflumic acid is a non-steroidal anti-inflammatory and analgesic drug. Different dosage forms and routes of administration have shown anti-inflammatory, analgesic and detumescence effects in animal experiments. It has been widely used in clinical studies that it has low toxicity, good tolerance, and better curative effect than other anti-inflammatory and analgesic drugs. This product does not cause sodium retention and can be used in elderly patients.
biological activity	Niflumic acid is a cyclooxygenase-2 (COX-2) inhibitor used to treat joint and muscle pain.
Target	Value
use	as a pharmaceutical intermediate

Last Update：2024-04-10 22:29:15

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ACIDUM NIFLUMICUM

Niflumic acid

CAS: 4394-00-7

Molecular Formula: C13H9F3N2O2

ACIDUM NIFLUMICUM - Names and Identifiers

ACIDUM NIFLUMICUM - Physico-chemical Properties

ACIDUM NIFLUMICUM - Risk and Safety

ACIDUM NIFLUMICUM - Reference Information

Supplier List

ACIDUM NIFLUMICUM Request for Quotation

Niflumic acid

CAS: 4394-00-7

Molecular Formula: C13H9F3N2O2

ACIDUM NIFLUMICUM - Names and Identifiers

ACIDUM NIFLUMICUM - Physico-chemical Properties

ACIDUM NIFLUMICUM - Risk and Safety

ACIDUM NIFLUMICUM - Reference Information

Supplier List

ACIDUM NIFLUMICUM